PAR-1 (protein kinase receptor 1, also known as thrombin receptor) is a member of the G protein-coupled receptor family, and its main ligand is thrombin. PAR-1 is mainly expressed in platelets, endothelial cells, smooth muscle cells and some neural cells, involved in hemostasis and atherosclerosis formation. At present, a great deal of research has also confirmed that PAR-1 is involved in epithelial-to-mesenchymal transition and epithelial-to-endothelial transformation; PAR-1 can regulate the NF-κB pathway, stimulate the formation of tumor angiogenesis, and participate in the development of tumors through a variety of ways. At the same time, the blood state of tumor patients often presents a hypercoagulable state. As one of the thrombin receptors, PAR-1 may participate in the formation of hypercoagulable state in tumor patients. The review focuses on the expression and activation mechanism of PAR-1 and its physiological pathological process; And how to participate in the occurrence and development of tumors and the relationship with cardiovascular diseases. The aim is to point out that PAR-1 may be a potential target for tumor therapy and may be helpful to improve the hypercoagulable state and prolong the survival of patients with advanced cancer.

Mengli Li, Zhiguang Zhao. Research on PAR-1 in Cancer, Cardiovascular Disease and Nerve-related Diseases. Frontiers in Medical Science Research (2023) Vol. 5, Issue 2: 1-8. https://doi.org/10.25236/FMSR.2023.050201.

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