Frontiers in Medical Science Research, 2023, 5(2); doi: 10.25236/FMSR.2023.050202.
Yingjie Hou1, Ping Li1, Jianing Li2
1Pharmacy, North China University of Science and Technology, Tangshan, China
2Pharmaceutical Preparation, North China University of Science and Technology, Tangshan, China
Cancer is one of the major diseases that endanger human life and health. Common anticancer drugs have high side effects and are prone to drug resistance, leading to treatment failure. Due to their special structures and lipophilicity, cage compounds have more pharmacological activities in their derivatives, such as antiviral, immune enhancing, and antitumor activities. Scientists have used cage compounds with good lipophilicity as structural units to develop new drugs with good selectivity, high efficiency and low toxicity. nIT-like nitroxide radicals have excellent antitumor activity, and this paper reviews the investigation of introducing cage structures into NIT-like nitroxide radicals to design and synthesize novel nitrogen oxides.
cancer, caged compounds, nitrogen-oxygen radicals, novel nitrogen oxides
Yingjie Hou, Ping Li, Jianing Li. Brief description of the synthesis of new nitrogen oxides. Frontiers in Medical Science Research (2023) Vol. 5, Issue 2: 9-12. https://doi.org/10.25236/FMSR.2023.050202.
[1] Thun M J, DeLancey J O, Center M M, et al. The global burden of cancer: priorities for prevention. Carcinogenesis, 2009, 31(1): 100-110.
[2] Yang Hongwei. Synthesis of novel 4-aryl-1, 4-dihydropyridine derivatives and their anti-lung cancer activity [D]. Anhui Medical University, 2017.
[3] Simeonova L., Gegova G., Galabov A.S. Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice.Antiviral Res., 95(2), 172-181, 2012.
[4] Yan Hong, Xing Guangjian, Zhou Lili, Huang Junying. Synthesis and application of cube and high cubic ane derivatives. Organic chemistry, 20 (5), 649-654, 2000.
[5] Liu J., Obando D., Liao V., Lifa T., Codd R.The many faces of the adamantyl group in drug design. Eur. J. Med. Chem., 46(6), 1949-1963, 2011.
[6] Svingen P.A., Tefferi A., Kottke T.J., Kaur G., Narayanan V.L., Sausville E.A., Kaufmann S.H. Effect of the Bcr/abl kinase inhibitors AG957 and NSC680410 on chronic myelogenous leukemia cells in vitro.Clin. Cancer Res., 6(1), 237-249, 2000.
[7] Mow B.M.F., Chandra J., Svingen P.A., Hallgren C.G., Weisberg E., Kottke T.J., Narayanan V.L., Litzow M.R., Griffin J.D., Sausville E.A., Tefferi A., Kaufmann S.H.Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC680410) on chronic myelogenous leukemia cells in vitro. Blood, 99(2), 664-671, 2002.
[8] Kaur G., Narayanan V.L., Risbood P.A., Hollingshead M.G., Stinson S.F., Varma R.K., Sausville E.A. Synthesis, structure-activity relationship, and p210(bcr-abl) protein tyrosine kinase activity of novel AG957 analogs. Bioorg. Med. Chem., 13(5), 1749-1761, 2005.
[9] Lewandowski M, Gwozdzinski K.Nitroxides as Antioxidants and Anticancer Drugs: [J].International Journal of Molecular Sciences., 18(11), 2490, 2017.
[10] Yokoi T, Otani T, Ishii K.In vivo fluorescence bioimaging of ascorbic acid in mice: Development of an efficient probe consisting of phthalocyanine, TEMPO, and albumin.[J].Scientific Reports., 8(1), 1560, 2018.
[11] Kim Y, Maciag A E, Cao Z, et al.PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells[J].Bioorganic & Medicinal Chemistry., 23(15), 4980-4988, 2015.
[12] Keane L J, Mirallai S I, Sweeney M, et al.Anti-Cancer Activity of Phenyl and Pyrid-2-yl 1,3-Substituted Benzo[1,2,4]triazin-7-ones and Stable Free Radical Precursors.[J].Molecules., 23(3), 574, 2018.
[13] Findlay V.J., Townsend D.M., Saavedra J.E., Buzard G.S., Citro M.L., Keefer L.K., Ji X.H., Tew K.D.Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. Mol. Pharmacol., 65(5), 1070-1079, 2004.
[14] Matsumoto K, Chase Z, Kohfeld K. Different mechanisms of silicic acid leakage and their biogeochemical consequences [J]. Paleoceanography, 2014, 29(3):238-254.
[15] Hou Zhiyou, Li Jing, Zhou Yongchun, Yang Mingjuan, Liu Haiqiang, Sun Xiaoli, Jing Linlin, Guo Guozhen. Radiation protection mechanism of NO-free radical R-1 in human hepatocyte L-02. Journal of Radiation Research and Radiation Technology, 31 (2), 172-176, 2011.
[16] Shi T.Y., Zhao D.Q., Wang H.B., Feng S., Liu S.B., Xing J.H., Qu Y., Gao P., Sun X.L., Zhao M.G..A new chiral pyrrolyl α-nitronyl nitroxide radical attenuates β-amyloid deposition and rescues memory deficits in a mouse model of Alzheimer Disease. Neurotherapeutics, 10(2), 340-353, 2013.
[17] Wang H.B., Gao P., Jing L.L., Qin X.Y., Sun X.L. The heart-protective mechanism of nitronyl nitroxide radicals on murine viral myocarditis induced by CVB3. Biochimie, 94(9), 1951-1959, 2012.
[18] Guo J., Zhang Y.J., Zhang J., Liang J., Zeng L.H., Guo G.Z. Anticancer effect of tert-butyl-2(4,5-dihydrogen-4,4,5,5tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2)-pyrrolidine-1-carboxylic ester on human hepatoma HepG2 cell line. Chem. Biol. Interact., 199(1), 38-48, 2012.