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Frontiers in Medical Science Research, 2023, 5(2); doi: 10.25236/FMSR.2023.050207.

Research Progress on Mechanism and Application of Zinc in Osteogenesis


Dongyao Li1, Shuai Zhao1, Guoqiang Xu1,2

Corresponding Author:
Dongyao Li

1Department of Prosthodontic Implantology, The First Affiliated Hospital of Xinjiang Medical University (Affiliated Stomatological Hospital), Urumqi, Xinjiang Uygur Autonomous Region, 830054, China

2Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, Xinjiang Uygur Autonomous Region, 830054, China


As the second most abundant trace metal element in the human body, zinc plays an important role in bone homeostasis and bone disease treatment. Adequate amounts of zinc not only mediates osteogenesis-related pathways through zinc dependent enzymes and zinc finger proteins to induce the differentiation of mesenchymal stem cells into osteoblasts and promote osteogenesis, but also inhibits osteoclast resorption activity, reducing bone resorption and thus promoting osteogenesis. In recent years, the importance of zinc in bone development, regeneration and homeostasis has been gradually discovered. The mechanism and application of zinc's osteogenic effect have been extensively studied. The aim of this paper is to summarize the research on zinc osteogenic mechanism and review its application research in bone tissue engineering in recent years.


zinc, osteogenic effect, osteoblasts, bone tissue engineering

Cite This Paper

Dongyao Li, Shuai Zhao, Guoqiang Xu. Research Progress on Mechanism and Application of Zinc in Osteogenesis. Frontiers in Medical Science Research (2023) Vol. 5, Issue 2: 43-49. https://doi.org/10.25236/FMSR.2023.050207.


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