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Frontiers in Medical Science Research, 2023, 5(3); doi: 10.25236/FMSR.2023.050301.

Therapeutic effects of different doses of peroperative intravenous dexmedetomidine for postoperative incision pain in rats


Yuansheng Wang1, Zihan Zhu1, Yuming Li2, Hongmei Dong3, Xiangjie Liu1, Zhibing Yan1, Fang Cheng1, Yanming Huang4

Corresponding Author:
Yanming Huang

1Department of Anesthesiology, Jiangmen Central Hospital, Jiangmen, 529030, China

2Department of Traditional Chinese Medicine, Jiangmen Central Hospital, Jiangmen, 529030, China

3Department of Cancer Research Center, Shantou University Medical College, Shantou, 515041, China

4Department of Respiration, Jiangmen Central Hospital, Jiangmen, 529030, China


It is essential to minimize postoperative pain immediately after an operation. We compared the effects of different doses of preoperative intravenous dexmedetomidine (DMED) on treating postoperative incision pain in rats. Forty healthy, male, and clean-grade Sprague-Dawley rats were randomly divided into five groups: group C, group B, group D1, group D2, and group D3. The rat hind-limb incision pain model was implemented. The cumulative pain score of each group was determined at two h after surgery. Western blotting was used to determine the spinal cord expression of PKC γ, and high-performance liquid chromatography was used to determine spinal cord glutamate levels. Compared with group C, group B had a significantly greater cumulative pain score and greater spinal cord levels of PKCγ and glutamate. There were significantly lower pain scores and levels of PKCγ and glutamate in groups D2 and D3 than in group D1. Perioperative DMED reduced the release of glutamate and inhibited the expression of PKCγ in the rat spinal cord and these changes correlated with reduced postoperative pain. The treatment effect was most evident at the highest tested dose of DMED (1 µg/kg).


dexmedetomidine, glutamate, protein kinase C, postoperative pain, peroperative, spinal cord, incision pain

Cite This Paper

Yuansheng Wang, Zihan Zhu, Yuming Li, Hongmei Dong, Xiangjie Liu, Zhibing Yan, Fang Cheng, Yanming Huang. Therapeutic effects of different doses of peroperative intravenous dexmedetomidine for postoperative incision pain in rats. Frontiers in Medical Science Research (2023) Vol. 5, Issue 3: 1-6. https://doi.org/10.25236/FMSR.2023.050301.


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