Objective: To systematically review the clinical efficacy and progress of Chinese medicine's external treatment method guided by the theory of simmering pus and growing flesh to promote postoperative wound repair in anorectology. Methods: Clinical randomized controlled trials (RCTs) of simmering pus and growing flesh method to promote postoperative wound healing in anorectology were collected by a computer search of China Knowledge Network (CNKI), Wanfang (WANGFANG DATA), VIP (VIP), China Biomedical Literature Database (CBM) and other means, and the screening of articles and the extraction of article data were performed according to the inclusion and exclusion criteria.Meta-analysis of the extracted data was also performed using Stata14 software, to compare the overall efficacy, mean wound healing time, and other clinical observations of patients with postoperative wounds in anorectal medicine by the external Chinese medicine method of simmering pus and growing flesh with the non-simmering pus and growing flesh method. Results: The final 12 publications were included, with a total of 931 study participants, and the Meta results showed that the TCM external treatment of simmering pus and growing flesh method helped to shorten the mean wound healing time [WMD=-3.791 , 95% CI (-4.629 , 2.952), P<0.05], improve the 14-day wound healing rate [WMD=9.341 , 95% CI (6.951 , 11.731), P<0.05], and improved postoperative wound recovery efficiency in anal diseases [RR=3.099, 95% CI (1.898, 5.060), P<0.05].Conclusion: The simmering pus and growing flesh method helps to improve the average healing time and wound healing rate of postoperative wounds in anal diseases, thus improving the efficiency of postoperative wound repair in anal diseases.

Xi Chen, Wenzhe Feng, Ruoxi Cao, Junhong Chen. A Systematic Review and Meta-analysis of the Use of Simmering Pus and Growing Flesh Method to Promote Postoperative Wound Healing in Anorectal Diseases. Frontiers in Medical Science Research (2023) Vol. 5, Issue 3: 14-23. https://doi.org/10.25236/FMSR.2023.050303.

[1] Zhou Pengfei., Liu Tianwen., Liu Shiju., et al. Application of the theory of "lifting pus and removing rot, simmering pus and growing flesh" in chronic perianal wounds [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2019, 21(08): 104-107.

[2] Liu Sheng, Tang Hanjun, Lu Deming. Application of the "simmering pus and growing flesh" method in Chinese medicine surgery [J]. Journal of Traditional Chinese Medicine, 2000, 07): 443.

[3] State Administration of Traditional Chinese Medicine. Diagnostic and efficacy criteria for Chinese medicine illnesses [S]. Beijing: China Medical Science and Technology Press, 2012.

[4] Guo Yaping, Ma Xi, Huang Xiaoming, et al. Clinical study of "simmering pus and growing flesh" method on postoperative trauma recovery of anal fissure [J]. Hebei Journal of Traditional Chinese Medicine, 2019, 34(02):20-22.

[5] Jin Lei. Discussion on the clinical efficacy of red furnace myogenic powder in postoperative wound exchange of anal fistula [J]. Chinese and foreign medicine, 2013, 32(30):43-44.

[6] Han Tianqi. Clinical observation of deer bone powder on postoperative trauma healing of anal fistula [D]. Jilin: Changchun University of Traditional Chinese Medicine,2019.

[7] Li Yan, Li Jingxiang. Clinical study on the healing of postoperative wounds of anal fissures with raw muscle and elephant skin cream [J]. Shandong Journal of Traditional Chinese Medicine, 2016,35(08):719-722.

[8] Tian Ying. Clinical study on the effect of raw muscle yuhong cream on postoperative healing of anal fistula [D]. Shandong: Shandong University of Traditional Chinese Medicine, 2010. 

[9] Li Jianghong. Clinical study on the combination of Shengmyu Hong cream and Jinxuan Hemorrhoid Fumigation San to promote postoperative wound healing in anorectal disease [D]. Hebei: Hebei Medical University, 2012.

[10] Feng Wenzhe. Clinical study on simmering pus and growing flesh with raw muscle yuhong cream to promote postoperative wound healing of anal fistula [D]. Shaanxi University of Traditional Chinese Medicine, 2008.

[11] Yang Jianhua, Wu Bensheng, Zhang Yihui. Clinical efficacy observation and safety analysis of simmering pus and growing flesh method in treating postoperative trauma of anal fistula [J]. Shizhen Guomao Guomao, 2018, 29(01):127-128.

[12] Zhen Shuguang, Yang Jianhua, Wang Xiaopeng, et al. Clinical study on the healing of postoperative trauma of anal fistula with Zihuang Sangmu cream[J]. Jiangxi Traditional Chinese Medicine, 2016, 47(06):52-53+59.

[13] Lu Lili, Zhong Qinguo, Zhou Wanni. Clinical study of simmering pus-generating cream on early postoperative wound healing of damp-heat anal fistula [J]. Heilongjiang Medicine, 2022, 35(02):287-289.

[14] Feng Wenzhe, Zhu Yinxiang. The efficacy of simmering pus and growing flesh method in treating 64 cases of postoperative trauma of anal fistula [J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2011, 35(02):184-185.

[15] Yang Huiju, Tong Ruoping, Li Min, et al. Clinical study on the treatment of chronic perianal wounds with sore healing cream based on the theory of simmering pus and generating muscle[J]. Journal of Traditional Chinese Medicine, 2020, 32(08):1565-1568.

[16] Shen Douyuan. Surgical Qixuan [M]. Beijing: People's Health Publishing House, 1955:8.

[17] Liu Xianzhou, Zhang Zhaohui, Zhu Zhaojun. On "simmering" pus and growing flesh versus "snuggling" pus and growing flesh [J]. Journal of Shanghai University of Traditional Chinese Medicine, 2017, 31(01):7-8+23.

[18] Fan Weijing, Wang Hongfei, Yang Baozhong, et al. On the application of simmering pus and growing flesh theory in the treatment of chronic refractory ulcers [J/OL]. Chinese Journal of Traditional Chinese Medicine Information: 1-3.

[19] TADEJ M. The use of Flivasorb in highly exuding wounds [J]. Br J Nurs, 2009, 18(15): S38, S40-S38, S42.