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Frontiers in Medical Science Research, 2023, 5(3); doi: 10.25236/FMSR.2023.050311.

Advances inprogrammed cell death in temporomandibular joint osteoarthritis


Peng Yu1,2, Yinghao Jing1,2, Zhongcheng Gong1,2

Corresponding Author:
Zhongcheng Gong

1Oncological Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Xinjiang Medical University, School/Hospital of Stomatology Xinjiang Medical University, Urumqi, 830054, Xinjiang Uygur Autonomous Region, China

2Stomatological Research Institute of Xinjiang Uygur Autonomous Region, Urumqi, 830054, Xinjiang Uygur Autonomous Region, China


Temporomandibular joint osteoarthritis (TMJOA) is a clinically common chronic degenerative disease of the TMJ. The degeneration of articular cartilage is a sort of typical pathological characteristics; and chondrocytes’ death is the kernel event in cartilaginous degeneration. Programmed cell death (PCD) has become a academic hotspot in the development of TMJ OA. Based on the concept, aetiology, morphological feature, pathogenesis of five well-known PCD including apoptosis, autophagy, pyroptosis, necroptosis and ferroptosis, as well as their recent research progresses on cartilage degeneration, this narrative review was designed and performed.


Apoptosis; Autophagy; Pyroptosis; Necroptosis; Ferroptosis; Osteoarthritis; Chondrocyte

Cite This Paper

Peng Yu, Yinghao Jing, Zhongcheng Gong. Advances inprogrammed cell death in temporomandibular joint osteoarthritis. Frontiers in Medical Science Research (2023) Vol. 5, Issue 3: 63-68. https://doi.org/10.25236/FMSR.2023.050311.


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