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Academic Journal of Engineering and Technology Science, 2019, 2(4); doi: 10.25236/AJETS.2019.020408.

Preparation of Mitomycin-Modified Chitosan Sustained-Release Membrane Based on Grey Theory


Chao Lin, Daguan Ke*

Corresponding Author:
Daguan Ke​

Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China

*Corresponding author


Chitosan is a kind of natural macromolecular polysaccharide with positive charge on glycosyl. Chitin is usually extracted from crustacean shell and formed by deacetylation of chitin. Chitosan is easier to be absorbed and utilized than chitin because it has removed the phthalide group from chitin through chemical treatment. Mitomycin-chitosan drug-loaded sustained-release membrane has good flexibility, permeability and hydrophilicity, and has certain drug sustained-release capability in vitro. Although the biological properties of chitosan are improved compared with chitin, chitosan can only be dissolved in weak acid solution, which greatly limits its application. In order to avoid propylation of the amino group of chitosan, chitin can be first reacted with epichlorohydrin and then deproteinized. This paper studies the properties of mitomycin-chitosan drug-loaded sustained-release membrane, evaluates its inhibitory effect on fibroblasts, biocompatibility and biodegradability in vitro experiments, and evaluates the feasibility of its application in the preparation of sustained-release membrane.


Chitosan, Mitomycin, Diaphragm, Sustained release

Cite This Paper

Chao Lin, Daguan Ke. Preparation of Mitomycin-Modified Chitosan Sustained-Release Membrane Based on Grey Theory. Academic Journal of Engineering and Technology Science (2019) Vol. 2 Issue 4: 53-60. https://doi.org/10.25236/AJETS.2019.020408.


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