Atrial fibrillation is a common arrhythmia with high incidence in clinic. With the rapid development of medical technology, interventional therapy for non-valvular atrial fibrillation has gradually matured and been widely used in clinic in recent years. However, the long-term effect of patients after treatment is not ideal, which leads to a greater risk of stroke and heart failure. Catheter ablation is an effective means to restore and maintain sinus rhythm in patients with atrial fibrillation, but its effect in improving stroke needs to be improved. Left atrial appendage occlusion is a minimally invasive technique in clinic, which can replace anticoagulants in the treatment of patients with non-valvular atrial fibrillation and effectively reduce the risk of stroke and bleeding. This thesis will review the development of catheter ablation combined with left atrial appendage occlusion in one-stop treatment of non-valvular atrial fibrillation.

Zhang Qianrong. Clinical Application Value of Catheter Ablation Combined with Left Atrial Appendage Occlusion in Non-valvular Atrial Fibrillation. Frontiers in Medical Science Research (2023) Vol. 5, Issue 4: 57-61. https://doi.org/10.25236/FMSR.2023.050410.

[1] Wazni OM, Marrouche N F, Martin DO, et al (2012). Radiofrequency Ablation vs Antiarrhythmic Drugs as First-line Treatment of Symptomatic Atrial Fibrillation: A Randomized Trial [J]. Jama the Journal of the American Medical Association, vol. 9, no. 21, pp. 1580-1580. 

[2] Jens Cosedis Nielsen, Arne Johannessen, Pekka Raatikainen, Et al. (2012)Radio frequency ablation as initial therapy in paroxymal fibrosis [J]. New England Journal of Medicine, vol. 367, no. 17, pp. 1587-1595. 

[3] Antti H, Fausto B, Cosedis N J, et al (2015). Radiofrequency ablation vs. Antiarrhythmic drug therapy as first line treatment of symptomatic atrial fibrillation: systematic review and meta-analysis [J]. Europace: European pacing, arrhythmias, and cardiac electrophysiology: journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, vol. 17, no. 3, pp. 370-378. 

[4] Haïssaguerre M, Jaïs P, Shah DC, et a1(1998). Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pul-monary veins, N Engl J Med, vol. 339, no. 10, pp. 659-666. 

[5] Andrade J G, Monir G , Pollak S J, et al. (2014) Pulmonary vein isolation using “contact force” ablation:The effect on dormant conduction and long-term freedom from recurrent atria l fibrillation — A prospective study [J]. Heart Rhythm, vol. 11, no. 11, pp. 1919-1924. 

[6] Shurrab M , Biase L D , Briceno D F , et al(2015). Impact of Contact Force Technology on Atrial Fibrillation Ablation: A Meta-Analysis. [J]. Journal of the American Heart Association, vol. 31, no. 9, p. 222. 

[7] Khan MN, Jais P, Cummings J, et al(2008). Pulmonary-vein isolation for atrial fibrillation in patients with heart failure. [J]. The New England journal of medicine, vol. 359, no. 17, pp. 1778-1785. 

[8] Huang Congxin, Zhang Shu, Huang Dejia, et al(2018). Atrial fibrillation: current understanding and treatment suggestions -2018 [J]. China Journal of Cardiac Pacing and Electrophysiology, vol. 32, no. 4, pp. 315-368. 

[9] Jing Weilin(2022). Effects of left atrial appendage occlusion and radiofrequency ablation on the quality of life of patients with atrial fibrillation at different ages [D]. Hebei Medical University. 

[10] Zhao Hongwei, Yin Xiaomeng, Wang Chengfu, et al(2019). Effect of Watchman left atrial appendage occlusion and oral rivaroxaban on stroke prevention in patients with nonvalvular atrial fibrillation [J]. Heart Journal, vol. 31, no. 06, pp. 673-676. 

[11] Li Yuanzhi, Li Yidan, Sun Lanlan, etc(2022). Left atrial strain for predicting recurrence in patients with non-valvular atrial fibrillation after catheter ablation: a single-center two-dimens ional speckle tracking retrospective study [J]. BMC Cardiovascular Disorders, vol. 22 no. 1, p. 468. 

[12] Cai Wenzhi, Sun Mingyu, Wang Zulu, et al(2022). Analysis of therapeutic effect and recurrence factors of young patients with nonvalvular atrial fibrillation after different catheter ablation [J]. Journal of Clinical Military Medicine, vol. 50, no. 10, pp. 1010-1014. 

[13] Nezu Mari, Ueda Shinichiro, Uchida Kazutaka, etc(2022). Association between body mass index and long-term clinical outcomes in patients with non-valvular atrial fibrillation taking oral anticoagulants. [J]. Heart and Vessels, vol. 10, no. 7, pp. 380-383. 

[14] Zhao Yao, Zhao Teng, Zhao Haijuan, et al(2022). Application progress of catheter ablation combined with left atrial appendage occlusion in patients with atrial fibrillation [J]. Journal of Naval Medical University, vol. 43, no. 8, pp. 936-942. 

[15] Wang Qunshan, Chen Mu, Sun Jian politician, et al(2020). Feasibility and perioperative safety analysis of catheter ablation of atrial fibrillation combined with left atrial appendage occlusion [J]. Chinese Journal of Cardiology, vol. 48, no. 10, pp. 842-847. 

[16] Ye Cong, Han Xuesong, Chen Yiming, etc (2022). Stroke prevention of thoracoscopic left atrial appendage clipping in patients with non-valvular atrial fibrillation at high risk of stroke and ble eding: study protocol for a non-randomised controlled clinical trial. [J]. BMJ open, vol. 12, no. 10, p. 63931. 

[17] Song Qunxia, Wang Lihong(2021). Analysis of influencing factors of new complications after catheter ablation combined with left atrial appendage occlusion [J]. Journal of Medical Imaging, vol. 31, no. 02, pp. 207-211. 

[18] Martsevich Sergey Yu., Lukina Yulia V., Kutishenko Natalia P., etc(2022). Analysis of Adverse Events in the Treatment of Patients with Non-Valvular Atrial Fibrillation with Oral Anticoagulants: Data from the “ANTEY” Obse rvational Study [J]. Pharmaceuticals, vol. 15, no. 10, pp. 1209-1213. 

[19] Dong Yan, Ren Jilai, Wang Xuecheng, et al(2021). Follow-up results of radiofrequency catheter ablation combined with left atrial appendage occlusion for nonvalvular atrial fibrillation [J]. Chinese Journal of Cardiac Arrhythmias, vol. 25, no. 6, pp. 504-509. 

[20] Xing Yu, Li Yinjun (2019). Comparative study on the efficacy and safety of rivaroxaban, dabigatran etexilate and warfarin in anticoagulant therapy for elderly patients with nonvalvular atrial fibrillation [J]. Journal of Cardiovascular and Cerebrovascular Diseases of Integrated Traditional Chinese and Western Medicine, vol. 17, no. 03, pp. 411-413. 

[21] Zeng Wanli, Huang Jijiang, Chu Wei (2017). Study on the application value of irrigation radiofrequency ablation in the surgical treatment of mitral valve disease complicated with atrial fibrillation [J]. China University Doctor, vol. 31, no. 03, pp. 209+211. 

[22] Wang Yunlu (2021). Study on one-stop treatment of persistent atrial fibrillation by radiofrequency ablation and left atrial appendage occlusion combined with radiofrequency ablation [D]. North Sichuan Medical College. 

[23] He Bin, Du Xianfeng, Liu Jing, et al (2017). Safety and effectiveness analysis of “one-stop” interventional therapy for nonvalvular atrial fibrillation [J]. Chinese Journal of Cardiac Arrhythmias, vol. 21, no. 3, pp. 197-202.